Comportamiento biológico de cementos óseos acrílicos con compuestos antioxidantes derivados de la vitamina E

Resumen

This paper reports on the biological response of an acrylic bone cement modified with antioxidant compounds derived from vitamin E. The biocompatibility of the new cement was tested in vitro through cell cultures and in vivo with animal experimentation in rabbits in which the cement was implanted in the dough state mimicking the clinical situation. The in vitro results revealed a good cellular colonization on the surface of the cement, non-citotoxicity of the eluates of the cement until 14 days, and a significant increase in cellular proliferation with respect to a PMMA bone cement. The histological analysis of the response to the novel cement indicated a good regeneration of the interface in the short and long terms, characterised by a big area of cement surrounded by newly formed bone, normal proliferation of the bone marrow and absence of fibrosis after 24 weeks of implantation.