Enhancing osseointegration: A proteomic evaluation and in vitro study of sol-gel surfaces doped with quercetin

Abstract

One of the main challenges in dental implantology is the success of osseointegration, the process by which a solid union is produced between a dental implant and the bone. In this context, sol-gel technology is beginning to be used to obtain biocompatible surfaces that interact favorably with the environment. By incorporating quercetin (QCT), a flavonoid with anti inflammatory properties to this sol-gel technology, this study aims to make a comparison between these sol-gel surfaces doped with quercetin (QCT sol-gel) and Ti surfaces, through a proteomic evaluation and in vitro HOb adhesion studies through confocal microscopy, observing a decrease of proteins related to the activation of the immune response and coagulation for the QCT sol-gel surfaces. In addition, an increase in the cellular area of HOb adhered to the QCT sol-gel surfaces was also observed.