Preparación de mallas mediante electrohilado para la inhibición de la angiogénesis

Abstract

Preparation of nanofibers by electrospinning is gaining much attention due to their potential application as drug delivery systems. The incorporation of the active compound in the polymeric matrix of the fibers prevents degradation and allows a controlled and localized delivery of the drug. Many diseases (psoriasis, diabetic retinopathy, tumor growth) have been related to alterations in the angiogenic processes, therefore the control of angiogenesis is being investigated as a possible treatment for these diseases. In this work poly(D, L-lactic acid) nanofibers loaded with sulfonated active compounds that inhibit heparin-dependent proangiogenic growth factors (5-amino acid-2-naphthalene sulfonic acid and poly(2-acrylamido-2-methylpropane sulfonic acid) have been prepared and characterized.