Polímeros acrílicos portadores de grupos naftalensulfónicos con actividad antiangiogénica

Resumen

Inhibition of angiogenesis-promoting factors such as fibroblast growth factors is considered to be a promising route to inhibit the growth and proliferation for solid tumours. The 5-amino-2-naphthalene sulfonic acid is a good inhibitor of the fibroblast growth factors. Its activity is based on the interaction with the union site of the fibroblast growth factors with the heparin. In this work 5-amine-2-naphthalene sulfonic acid has been incorporated into polymeric chains by radical copolymerization with monomers widely used in biomedicine. Inhibition of fibroblast growth factor mitogenic activity was studies “in vitro” and promising results were obtained. Polymeric drugs that incorporate ANSA in their structure seem good candidates in the development of new therapeutics against some FGF- dependent cancers.